Investigation into the Case of the Missing AF

Well folks, it has been quite the day!
DW and I both seem to have some kind of mild flu. I never get the flu. And this year, I actually got the flu shot!! Wtf? The last time I can remember having it was sometime in 2005, and it was complete with bedsheet-soaking fever and chills, loss of appetite, and diarrhea. It lasted about 3 days, and cost me about 7lbs of my already emaciated frame. Luckily, I am no longer this skinny, and this round has not come close to being that bad. For me, it’s still a mild fever and chills, body aches, and my favourite: the runs. Seriously, I tore into a new package of toilet paper recently, and stocked the bathroom with two extra rolls. Just in case.

Now, feeling like shit would be a whole lot nicer if I knew where the fuck AF has been hiding out. Yes, it has come to this. I know I’m starting to sound like a broken record, or like your significant other nagging you about why it’s necessary to keep 13 bottles of supplements on the kitchen counter permanently, but I am seriously frustrated.

Let me put this into perspective for you.

This is what the Long Lupron Protocol for IVF is supposed to look like:
Day 21 Precycle: start Lupron and stay on it until near the end of IVF stims
Day 28 Precycle: get period –> this becomes Day 1 of Treatment Cycle
Day 3 Treatment Cycle: start stims (Gonal-F for me), lower Lupron dose
Day 13-15: HCG trigger
Day 15-17: egg retrieval

This is what it looks like so far for me:
Day 21 Precycle: start Lupron (and Provera because not yet ovulated)
Day 28: no period
Day 29: still no period
Day 30: still no period
Day 31: still no period
Day 32: still no period
Day 33: still no period
Day 34: still no period
Day 35: still no period
Day 36 (today): STILL NO PERIOD!!!

Notice how in an ideal cycle, you’re on the high dose Lupron for 7 days before your period, but I‘ve been on Lupron for over 15 days now. Lupron causes weight gain, headaches, and major irritability. So yeah. I’m kind of losing my mind.

Early this morning, I went to the fertility clinic for bloodwork, a full bladder pelvic ultrasound, and a transvaginal ultrasound to figure out what the hell is going on. This appointment went well.

The ultrasounds revealed that:
– my endometrial lining is 8.4mm thick
– I have no cysts (hallelujah! I was so worried about this)
– I have 14 antral follicles (6 on the R, 8 on the L) just chillin’, waiting to be stimmed

Last year, during our baseline for IVF#1, I had 16 antral follicles, so time does seem to be showing an influence here. I was reading a research paper on antral follicle numbers, and apparently they are grouped into three ranges: less than 3 (poor ovarian reserve) , less than 6 (average ovarian reserve), greater than 9 (high ovarian reserve). So with 14, I’m still looking really good.

I still had to wait for the bloodwork results, which would be available this afternoon.

By the early afternoon, I got a call from the head nurse.
Apparently, my blood results were in, and they were abnormal:
Estrogen 360 (way too high, should be less than 250)
Progesterone close to zero
She wanted me to keep on the 10 units of Lupron for another week, and then we would recheck my levels.

I thought this was really weird. It didn’t make sense because I was definitely feeling my classic progesterone signs- sore breasts, back ache, dairy cravings. So before she could hang up, I asked more questions, really nit-picking about the values, which required her to go back to her computer and consult my bloodwork results.

There was a pause. An extended silence.

And then she spoke.

She had planned my next steps based on the WRONG results!! Those results were from my pre-Lupron scan, not today!! My results from today had not yet be logged, so more waiting…

I took the dogs shopping, as Clementine needed a new winter coat. Then I took the dogs to the conservation lands for a hike. The paths were all iced over, and I was glad to have my grippy strap-ons (for my boots). When we got back to the car, I noticed that I had a voicemail from the fertility nurse (no missed call- she sent it straight to voicemail):

My levels for today were actually:
Estrogen 74 (nice and low- they want it to be less than 250 to be cleared to start)
Progesterone 1.71 (nice and low- period should be here soon)
My period looks to be due any day now, with my progesterone being so low, so they want me to just call when my period shows up, and then I guess I go in again for my baseline (I actually hope I don’t have to, since everything looks good today).

I found this online, and really liked how it presents estrogen and progesterone levels throughout a typical cycle:

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Also, my BBT temp went down a bit today:

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So all signs- blood, temperature, and ultrasound- point to AF coming soon. But I’m checking every chance I get, and soon can’t seem to come soon enough.

Provera, Diarrhea, and Waiting for AF

What a title eh?

Well, I finished my last dose of Provera on Saturday night. I was on a 10mg daily dose for 7 days, overlapping with Lupron. The Provera didn’t make me sleepy like the oral Prometrium usually does, which was disappointing (especially for the insomnia).

Some side effects that I did notice from the Provera were:
– constant back ache
– sore breasts toward the latter end of the week
– cramps roughly 12 hours after each dose, with the worst cramps from days 3-5, lasting 1-2 hours
– frequent urination at night- 3-4 times a night
– major constipation!

It’s hard to tease out what side effects were from the Lupron, but after consulting with the information sheet that came with my medication, as well as some IVF blogs, I think the following side effects are care of Lupron:
– super hungry (increases cell uptake of blood sugar and causes hypoglycaemia)
– insomnia
– mild headaches

For two days now, I’ve only been on the Lupron, and I’ve had the headaches. They aren’t bad, but have me retreating into the depths of a dark bedroom for a while.

As the Provera wears off, so has the constipation. Today, I have had frequent episodes of the runs. Fun times. Notice that I didn’t give you a TMI warning? (People who want babies should become desensitized to poop issues.) Diarrhea is a good thing though, as I would like my meals from three days ago to finally vacate my body. Diarrhea also means that my period is coming… Soon! *Fingers crossed* I can’t wait for CD1 and to start my stimulation drugs!

I have been tracking my BBT the past two days, so that I can get an idea of when to expect AF. Many women report not getting their period for up to two weeks after stopping Provera, so I’m a bit anxious about it. I’m super OCD about scheduling, so waiting for AF is pure torture for me. But my BBT has been hopeful, as this morning, my temperature dropped almost to half of the overall spike temperature. So I might start to bleed any day now. My withdrawal bleeds after Endometrin came three days later, so if I am consistent with that, I should get my period late tonight, or tomorrow.

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For now, we wait.

Fresh New Cycle and Fertility Clinic Frustrations

So yesterday I started my first period since the D&C. It took 26 days for it to begin, and so far it’s been pain-free.

Yesterday the bleeding was light, and today it has been heavy but without cramping. Most of my periods prior to TTC have been pain free, and it wasn’t until starting all of the fertility drugs that I started to have more painful periods. So, so far, this feels cleansing.
I am excited to see how my BBT looks for this upcoming cycle, because my post D&C BBT was wonky. I had some egg white cervical mucus for two days, which indicates that I maybe ovulated, but my luteal phase was only 6 days, and there was not a distinctive temperature shift. My body temperature was also really low, which was weird. This cycle has already started off 0.5 degrees Celsius warmer.

On the weekend we celebrated Canadian Thanksgiving with my in-laws at the cottage. We started the process of closing the cottage for the winter, bringing in the dock, clearing out the fridge. The whole family stayed overnight, and we got to spend a lot of time with our niece and nephew.

One afternoon, I was playing with our 8 year old niece, when she pulled out this book:

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I asked if she wanted to read it to me (to practice her reading out loud), but she didn’t. She wanted me to read it to her. I took a breath, braced myself, and started reading. She cuddled into me, and at one point, I started to well up with tears. The words seemed to hit a chord, and I thought that I could not continue. I took another deep breath, put on a smile, and continued on without her even noticing.

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That night, I couldn’t sleep. I started reading Ann-Marie MacDonald’s new book, Adult Onset, which really was not a good thing for me to begin, given that there are a lot of flashbacks to the main character’s mother’s multiple miscarriages/stillbirths. In bed, I started crying, then fully weeping, while DW pulled me into her chest. I didn’t sleep at all Thanksgiving night.

In other news, I’ve started the process of cleaning out our garden. The weather has been warmer than expected, so the soil is easier to work. Today, I pulled up all of our rainbow carrots, beets, and harvested some brussel sprouts.

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I roasted some with maple syrup, and they were delicious.

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Lastly, I wanted to share my frustration with our fertility clinic. I emailed my primary nurse almost two weeks ago about getting the immune blood panel done, then emailed her again a few days ago, and then called and left a voicemail today, and she still hasn’t gotten back to me. DWS emailed her at the same time two weeks ago, and she got a reply. I’m not sure why, but it seems like she is avoiding me. It is super frustrating for me because I’m anticipating my next cycle to be in about 4 weeks, and want the immune results to come back before we transfer the last embryo. Yes, we plan to transfer the last embryo probably sometime in December. I just want to rule out any issues with staying pregnant, so that we maximize our chances with this last embryo. I don’t know why our nurse won’t get back to me with a yes or no from the RE. It is super frustrating.

Anyways, new cycle, new beginnings.